Inhibition of HERG potassium channels by domiphen bromide and didecyl dimethylammonium bromide

Mechanism of HERG potassium channel inhibition by tetra-n-octylammoniumbromide,benzethonium chloride, domiphen bromide and didecyldimethylammonium bromide

The surface and solution properties of dihexadecyl dimethylammonium bromide.

The surface adsorption behavior and solution aggregate microstructure of the dichain cationic surfactant dihexadecyl dimethylammonium bromide (DHDAB) have been studied using small angle neutron scattering (SANS), light scattering, neutron reflectivity (NR), and surface tension (ST). Using a combination of surface tension and neutron reflectivity, the DHDAB equilibrium surface excess at saturati...

Inhibition of hERG Potassium Channels by Celecoxib and Its Mechanism

BACKGROUND Celecoxib (Celebrex), a widely prescribed selective inhibitor of cyclooxygenase-2, can modulate ion channels independently of cyclooxygenase inhibition. Clinically relevant concentrations of celecoxib can affect ionic currents and alter functioning of neurons and myocytes. In particular, inhibition of Kv2.1 channels by celecoxib leads to arrhythmic beating of Drosophila heart and of ...

Inhibition of granulocyte migration by tiotropium bromide

STUDY OBJECTIVES Neutrophil influx into the airways is an important mechanism in the pathophysiology of the inflammatory process in the airways of patients with chronic obstructive pulmonary disease (COPD). Previously it was shown that anticholinergic drugs reduce the release of non-neuronal paracrine mediators, which modulate inflammation in the airways. On this basis, we investigated the abil...

Sir Charles Locock and potassium bromide.

On 12 May 1857, Edward Sieveking read a paper on epilepsy to the Royal Medical and Chirurgical Society in London. During the discussion that followed Sir Charles Locock, obstetrician to Queen Victoria, was reported to have commented that during the past 14 months he had used potassium bromide to successfully stop epileptic seizures in all but one of 14 or 15 women with 'hysterical' or catamenia...